Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated 68 Ga PSMA and 99m Tc HDP Uptake with No Signs of Malignancy.
Morten BentestuenMaria Carlsen ElkjærHelle Damgaard ZachoPublished in: World journal of nuclear medicine (2022)
Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( 68 Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, 68 Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, 68 Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.
Keyphrases
- pet ct
- positron emission tomography
- prostate cancer
- radical prostatectomy
- computed tomography
- bone mineral density
- bone marrow
- pet imaging
- soft tissue
- dual energy
- newly diagnosed
- bone regeneration
- bone loss
- image quality
- contrast enhanced
- magnetic resonance imaging
- mesenchymal stem cells
- case report
- single cell
- silver nanoparticles