Association of MAPT subhaplotypes with clinical and demographic features in Parkinson's disease.
Angela B DeutschlanderTakuya KonnoAlexandra I Soto-BeasleyRonald L WaltonJay A van GerpenRyan J UittiMichael G HeckmanZbigniew K WszolekOwen A RossPublished in: Annals of clinical and translational neurology (2020)
Four MAPT H1 subhaplotypes, but not the H2 haplotype, were significantly associated with specific clinical features in Parkinson's disease. MAPT haplotypic structure may explain some of the phenotypic variability in disease. Replication of our findings will be critical to fully resolve the Parkinson's disease risk association signal at Chr17q21.
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