In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.

Valeria CuccariniLuigi AntelmiBianca PolloRosina PaterraChiara CalatozzoloAnna NigriFrancesco DiMecoMarica EoliGaetano FinocchiaroGreta BrennaIrene TramacereMaria Grazia BruzzoneElena Anghileri

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)

Our data confirm that 2 × 2 × 2-cm3 voxel TE 97 MRS shows high accuracy for 2HG detection, with good sensitivity and 100% specificity in distinguishing IDH mutant gliomas. Main limits of the technique are small tumor volume and low cellularity. Integrating 2HG-MRS with other metabolites may help non-invasive diagnosis of glioma, prognostic assessment, and treatment planning in clinical setting.

Keyphrases

high grade
ms ms
big data
wild type
living cells
machine learning
combination therapy
loop mediated isothermal amplification
real time pcr
data analysis