Bone marrow stem cells incubated with ellipticine regenerate articular cartilage by attenuating inflammation and cartilage degradation in rabbit model.

Mohammad Amjad Hossain Soyeon Lim Kiran D Bhilare Md Jahangir Alam Baicheng Chen Ajay Vijayakumar Hakyoung Yoon Chang Won Kang Jong-Hoon Kim

Published in: Journal of veterinary science (2023)

The transplantation of Ellip.+BMSCs normalized the OA condition by boosting the recovery of degenerated articular cartilage and inhibiting the catabolic signaling pathway.

Keyphrases

signaling pathway
stem cells
bone marrow
cell therapy
pi k akt
oxidative stress
mesenchymal stem cells
induced apoptosis
epithelial mesenchymal transition
knee osteoarthritis
extracellular matrix
endoplasmic reticulum stress