Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy.

You Goh Muhammad Zulfiqah Sadikan Heethal Jaiprakash Nurul Alimah Abdul Nasir Renu Agarwal Igor Iezhitsa Nafeeza Mohd Ismail

Published in: BMC complementary medicine and therapies (2024)

Oral TRF therapy for 12 weeks lowers retinal cell apoptosis by decreasing pro- and increasing anti-apoptotic markers. The preservation of visual behaviour in a two-chamber mirror test supported these retinal molecular alterations in diabetic rats.

Keyphrases

diabetic retinopathy
diabetic rats
oxidative stress
optical coherence tomography
cell proliferation
cell death
anti inflammatory
metabolic syndrome
high fat diet
single molecule
gestational age
preterm birth
stress induced