Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.

Cristina M LanataJoanne NitithamKimberly E TaylorSharon A ChungDara G TorgersonMichael F SeldinBernardo A Pons-EstelTeresa Tusié-LunaBetty P TsaoEric F MorandMarta E Alarcón-RiquelmeLindsey A Criswell

Published in: PloS one (2018)

Distinct genetic factors are associated with the risk of LN in SLE patients of different ethnicities. CKD risk alleles may play a role in the development of LN in addition to SLE-associated risk variants. These findings may further explain the clinical heterogeneity of LN risk and response to therapy observed between different ethnic groups.

Keyphrases

end stage renal disease
systemic lupus erythematosus
chronic kidney disease
ejection fraction
copy number
stem cells
rheumatoid arthritis
mesenchymal stem cells
smoking cessation