Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders.
Jurgen SotaSilvana GuerrieroGiuseppe LopalcoAbdurrahman TufanGaafar RagabIbrahim AlMaglouthMarcello GovoniPetros P SfikakisMicol FrassiAntonio VitaleRiza Can KardasPaola TriggianeseMaria Sole ChimentiAos A AboabatMatteo PigaSara MontiGian Domenico SebastianiDerya YildirimAlessandro ConfortiStefano GentileschiRosanna DammaccoAndrea Hinojosa-AzaolaPerla Ayumi Kawakami-CamposFrancesca RuffilliJiram Torres-RuizMaissa ThabetAmira AtigPiero RuscittiGiulia CataldiOmbretta ViapianaGülen HatemiAlican KarakoçStefania CostiAnnamaria IagnoccoFrancesca CrisafulliGeorge FragoulisEmanuela Del GiudiceMohamed Tharwat HegazyMaria Pia ParoliAli ŞahinMaria MorroneFlorenzo IannoneDaniela Opris-BelinskiKazi Nur AsfinaPatrizia BaroneCarla GaggianoHamit KucukMaria Francesca GicchinoFrancesco CarubbiValeria CaggianoKaterina LaskariSamar TharwatHaner DireskeneliFatma Alibaz-OnerGizem SevikArmin MaierAhmed Hatem LaymounaGiacomo EmmiNurullah AkkoçMaria TarsiaJessica SbalchieroGiovanni ContiRosaria SpinellaFrancesco La TorreEnrico TombettiRana Hussein AminAngela MauroAnastasios KaramanakosEster CarreñoAlex FonollosaMarco CattaliniLuciana BredaAlejandra de-la-TorreEwa Wiesik-SzewczykCarlos Cifuentes-GonzálezSeza OzenMaria Antonietta MazzeiGian Marco TosiBruno FredianiAlberto BalistreriEzgi Deniz BatuVishali GuptaLuca CantariniClaudia FabianiPublished in: Ocular immunology and inflammation (2024)
Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.