An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination.
Danna SheinboimShivang ParikhPaulee ManichIrit MarkusSapir DahanRoma ParikhElisa StubbsGali CohenValentina Zemser-WernerRachel E BellSara Arciniegas RuizRuth PercikRonen BrennerStav LeibouHananya VaknineGali AradYariv GerberLital Keinan-BokerTal ShimonyLior BikovskiNir GoldsteinKeren ConstantiniSapir LabesMordechai ShimonovHila DoronAriel IonescuTamar ZivEran NizriGuy ChoshenHagit Eldar-FinkelmanYuval TabachAharon HelmanShamgar Ben-EliyahuNeta ErezEran PerlsonTamar GeigerDanny Ben-ZviMehdi KhaledYftach GepnerCarmit LevyPublished in: Cancer research (2022)
Exercise protects against cancer progression and metastasis by inducing a high nutrient demand in internal organs, indicating that reducing nutrient availability to tumor cells represents a potential strategy to prevent metastasis. See related commentary by Zerhouni and Piskounova, p. 4124.