Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1.
Kunlong ZhangJun LuFang FangYongping ZhangJuanjuan YuYanfang TaoWenyuan LiuLihui LuZi-Mu ZhangXinran ChuJianwei WangXiaolu LiYuanyuan TianZhiheng LiQian LiXu SangLi MaNingling WangJian PanShao-Yan HuPublished in: Journal of immunology research (2023)
Our results suggested that FYB1 gene played important role in regulating self-renewal of T-ALL cells by activating IGLL1, representing a promising therapeutic target for T-ALL patients.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- signaling pathway
- induced apoptosis
- transcription factor
- genome wide
- ejection fraction
- newly diagnosed
- copy number
- chronic kidney disease
- genome wide identification
- cell cycle arrest
- dna methylation
- gene expression
- oxidative stress
- acute myeloid leukemia
- cell death