The efficacy and safety of pyrotinib in treating HER2-positive breast cancer patients with brain metastasis: A multicenter study.

Huaxu LiuChao FuShanshan LiFang ChenYongteng YangChunjian WangJie QinShuaishuai LiuRanran ZhangChangyuan WangJinbao ZongLiping MengXiangjiao Meng

Published in: Cancer medicine (2021)

Pyrotinib combined with chemotherapy/radiotherapy or alone showed significantly greater local control rates and progression free survival (PFS), with manageable toxicity for patients with HER2-positive breast cancer with brain metastases, and further follow-up will provide an overall survival (OS) data.

Keyphrases

positive breast cancer
free survival
brain metastases
small cell lung cancer
locally advanced
early stage
electronic health record
white matter
radiation therapy
rectal cancer
resting state
oxidative stress
squamous cell carcinoma
big data
radiation induced
cerebral ischemia
machine learning
oxide nanoparticles