Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.
Geke Aline BoerJenna Elizabeth HuntMaria Buur Nordskov GabeJohanne Agerlin WindeløvAlexander Hovard Sparre-UlrichBolette HartmannJens Juul HolstMette Marie RosenkildePublished in: British journal of pharmacology (2022)
mGIPAnt-1 successfully inhibited acute GIP-induced effects in vitro and in vivo and sub-chronically induces resistance to HFD-induced weight gain in ovariectomised mice. Our results support the development of GIP antagonists for the therapy of obesity.
Keyphrases
- weight gain
- high fat diet
- body mass index
- birth weight
- insulin resistance
- high fat diet induced
- adipose tissue
- high glucose
- drug induced
- weight loss
- diabetic rats
- skeletal muscle
- metabolic syndrome
- liver failure
- stem cells
- physical activity
- mesenchymal stem cells
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- gestational age