Metabolic regulation by prostaglandin E 2 impairs lung group 2 innate lymphoid cell responses.

Calum T RobbYou ZhouJennifer M FeltonBirong ZhangMarie GoeppPrivjyot JheetaDanielle J SmythRodger DuffinSonja VermerenRichard M BreyerShuh NarumiyaHenry J McSorleyRick M MaizelsJürgen K J SchwarzeAdriano G RossiChengcan Yao

Published in: Allergy (2022)

-EP4-cAMP and energy metabolic pathways may provide novel opportunities for treating the ILC2-initiated lung inflammation in asthma and NERD.

Keyphrases

oxidative stress
chronic obstructive pulmonary disease
single cell
cell therapy
stem cells
allergic rhinitis
cystic fibrosis