Synthesis of highly substituted isoquinolines/isoquinolones by ruthenium (II)-catalyzed reaction of benzyl/α-methyl benzyl/benzoyl isocyanates with diaryl alkynes.
Amrendra KumarShubham JaiswalTadigoppula NarenderPublished in: Chemical communications (Cambridge, England) (2023)
An efficient and novel method has been developed for the synthesis of highly substituted isoquinolines/isoquinolones by Ru(II)-catalyzed intermolecular oxidative annulation of benzyl/benzoyl isocyanates with diaryl alkynes in the presence of Cs 2 CO 3 as base and Cu(OTf) 2 as an oxidant at 120 °C for 1 h.