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Uncovering the Impact of Aggrephagy in the Development of Alzheimer's Disease: Insights Into Diagnostic and Therapeutic Approaches from Machine Learning Analysis.

Jiayu XuSiqi GouXueyuan HuangJieying ZhangXuancheng ZhouXiangjin GongJingwen XiongHao ChiGuanhu Yang
Published in: Current Alzheimer research (2024)
Our findings not only contribute to a deeper understanding of the molecular mechanisms underlying AD but also offer valuable insights for drug development and clinical analysis. The limitation of our study is the limited sample size, and although AD-related genes were identified and some of the mechanisms elucidated, further experiments are needed to elucidate the more in-depth mechanisms of these characterized genes in the disease.
Keyphrases
  • machine learning
  • genome wide
  • cognitive decline
  • optical coherence tomography
  • gene expression
  • deep learning
  • big data
  • dna methylation
  • single molecule
  • transcription factor