A smart perylene derived photosensitizer for lysosome-targeted and self-assessed photodynamic therapy.

Niu NiuHuipeng ZhouNing LiuHong JiangEjaz HussainZhenzhen HuCong Yu

Published in: Chemical communications (Cambridge, England) (2019)

A perylene probe PC4 is explored as a smart lysosome-targeted photosensitizer. It can efficiently kill cancer cells and also mark dead cells with bright fluorescence emission in nuclei for real-time monitoring and assessing of the photodynamic therapeutic efficiency.

Keyphrases

photodynamic therapy
cancer therapy
living cells
fluorescent probe
fluorescence imaging
induced apoptosis
single molecule
cell cycle arrest
drug delivery
quantum dots
endoplasmic reticulum stress
cell death