miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

Daijiro HoriBrittany Dunkerly-EyringYohei NomuraDebjit BiswasJochen SteppanJorge Henao-MejiaHideo AdachiLakshmi SanthanamDan E BerkowitzCharles SteenbergenRichard A FlavellSamarjit Das

Published in: PloS one (2017)

Decreased miR-181b with aging plays a critical role in ECM remodeling by removing the brake on the TGF-β, pSMAD2/3 pathway.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
extracellular matrix