PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation.
Sudipta BaroiPiotr J CzernikMohd Parvez KhanJoshua LetsonEmily CroweAmit ChougulePatrick R GriffinClifford J RosenBeata Lecka-CzernikPublished in: bioRxiv : the preprint server for biology (2024)
Osteocytes function as a body energostat via their bioenergeticsPPARG protein acts as a "molecular break" of osteocyte mitochondrial activityPPARG deficiency activates TCA cycle, oxidative stress and ROS accumulationPPARG controls osteocyte insulin signaling and fuel utilization.
Keyphrases
- oxidative stress
- dna damage
- type diabetes
- single cell
- cell therapy
- cell death
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- reactive oxygen species
- stem cells
- amino acid
- binding protein
- single molecule
- replacement therapy
- metabolic syndrome
- insulin resistance
- small molecule
- mesenchymal stem cells
- adipose tissue
- heat shock protein