Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.
Huaxin SunJie SongKai LiYao LiLuxiang ShangQina ZhouYanmei LuYazhen ZongXiuyuan HeMuzappar KariHang YangXianhui ZhouLing ZhangBao-Peng TangPublished in: Clinical science (London, England : 1979) (2023)
Suppressing β1-AAbs effectively protects the atrial vulnerable substrate by ameliorating intracellular Ca2+ mishandling and atrial fibrosis, preventing the process of the autoimmune associated AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- percutaneous coronary intervention
- multiple sclerosis
- protein kinase
- signaling pathway
- amino acid
- left ventricular
- liver fibrosis
- coronary artery disease
- reactive oxygen species
- structural basis
- binding protein