Clinical characteristics and outcomes of acute hepatitis a in Korea: a nationwide multicenter study.
Sung-Youn KwonSang Hoon ParkJong Eun YeonSook Hyang JeongOh Sang KwonJin Woo LeeHong Soo KimYeon Seok SeoYoung Seok KimJoo Hyun SohnHyung Joon YimJong Young ChoiMyung Seok LeeYoung Oh KweonJae Youn CheongHaak Cheoul KimHeon Ju LeeSoon Koo BaikHyonggin AnKwan Soo ByunPublished in: Journal of Korean medical science (2014)
The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- multiple sclerosis
- healthcare
- mental health
- hepatitis b virus
- adipose tissue
- hepatitis c virus
- insulin resistance
- artificial intelligence
- human immunodeficiency virus
- weight loss
- mechanical ventilation
- patient reported
- aortic dissection
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation