PyRICo-Pilot: pyridostigmine to reduce the duration of postoperative ileus after colorectal surgery - a phase II study.

Nagendra N Dudi-Venkata Hidde M Kroon Sergei BedrikovetskiLuke TraegerMark LewisMatthew J LawrenceRonald A HunterJames W MooreMichelle L ThomasTarik Sammour

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)

Oral pyridostigmine appears to be safe to use after elective colorectal surgery in a select group of patients. However, considering this is a pilot study with a small sample size, larger controlled studies are needed to confirm this finding and establish efficacy for prevention of POI.

Keyphrases

phase ii study
end stage renal disease
patients undergoing
ejection fraction
newly diagnosed
chronic kidney disease
open label
peritoneal dialysis
locally advanced
prognostic factors
clinical trial
squamous cell carcinoma
study protocol
radiation therapy
patient reported outcomes
rectal cancer