Direct prospective comparison of 18F-FDG PET and arterial spin labelling MR using simultaneous PET/MR in patients referred for diagnosis of dementia.
Jenny CeccariniSophie BourgeoisDonatienne Van WeehaegheKarolien GoffinRik VandenbergheMathieu VandenbulckeStefan SunaertKoen Van LaerePublished in: European journal of nuclear medicine and molecular imaging (2020)
In a direct head-to-head comparison on a simultaneous GE Signa PET/MR, 18F-FDG PET performed better compared with ASL in terms of sensitivity and reader confidence, as well as volume and intensity of abnormalities. However, using pure semiquantitative analysis, similar diagnostic accuracy between the two modalities was obtained. Therefore, ASL may still serve as complement to neuroreceptor or protein deposition PET studies when a single simultaneous investigation is warranted.
Keyphrases
- pet ct
- positron emission tomography
- pet imaging
- computed tomography
- end stage renal disease
- contrast enhanced
- magnetic resonance
- chronic kidney disease
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- mild cognitive impairment
- peritoneal dialysis
- small molecule
- high intensity
- cerebral blood flow
- patient reported outcomes
- optical coherence tomography