A regioselective step-by-step C 60 Cl 6 functionalization approach affords a novel family of C 60 Ar 5 Th'Th''H fullerene derivatives with promising antiviral properties.

We report a novel reaction of the recently discovered family of fullerene derivatives C 1 -C 60 Ar 5 Th' with thiophene derivatives Th''H yielding a previously unknown family of C 1 -C 60 Ar 5 Th'Th''H compounds with three different types of functional aromatic addends attached to the carbon cage. The discovered reaction paves a way to the synthesis of novel C 60 fullerene derivatives with promising antioxidant and antiviral properties.