Enantioselective Synthesis of Silacyclopentanes.

Kazunobu IgawaDaisuke YoshihiroYusuke AbeKatsuhiko Tomooka

Published in: Angewandte Chemie (International ed. in English) (2016)

A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

Keyphrases

density functional theory
quantum dots
molecular dynamics
molecularly imprinted
molecular dynamics simulations
high throughput
molecular docking
protein protein
mass spectrometry
crystal structure
liquid chromatography
electron transfer
solid phase extraction