Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome.
Magdalena KalinowskaMathijs B van der LeiMichael KitiashviliMaggie MamcarzMauricio M OliveiraFrancesco LongoEric KlannPublished in: Molecular autism (2022)
Our findings indicate a cell type-specific role for FMRP in parvalbumin-expressing neurons in regulating distinct behavioral features associated with FXS.