Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/ DICER1 Registry.
Kris Ann P SchultzAnne K HarrisAlexander T NelsonDave WatsonJohn T LucasDoug MiniatiDouglas R StewartKelly N HagedornWilliam MizeJunne KamiharaSarah G MitchellDavid B WilsonKatie GettingerArun A RangaswamiLaura A HarneyCarlos Rodriguez GalindoGianni BisognoLouis P DehnerD Ashley HillYoav H MessingerPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
The use of IVADo in children with type II and type III PPB resulted in similar-to-improved outcomes compared with historical controls. Inferior outcomes with metastatic disease suggest the need for novel therapies. This large cohort of uniformly treated children with advanced PPB serves as a benchmark for future multicenter therapeutic studies for this rare pediatric tumor.