Single-cell image analysis reveals a protective role for microglia in glioblastoma.
Zoe WoolfMolly E V SwansonLeon C D SmythEdward W MeePatrick SchwederPeter HeppnerBernard J H KimClinton TurnerRobyn L OldfieldMaurice A CurtisRichard L M FaullEmma L ScotterThomas In Hyeup ParkMichael DragunowPublished in: Neuro-oncology advances (2021)
We demonstrate the validity of previously defined microglial-specific genes P2RY12 and TMEM119 as robust discriminators of microglia and TAMs at the protein level in human tissue. Moreover, our data suggest that a higher proportion of microglia may be beneficial for patient survival in glioblastoma. Accordingly, this tissue-based method for myeloid population differentiation could serve as a useful prognostic tool.
Keyphrases
- inflammatory response
- neuropathic pain
- single cell
- lipopolysaccharide induced
- endothelial cells
- lps induced
- spinal cord injury
- spinal cord
- rna seq
- dendritic cells
- high throughput
- electronic health record
- acute myeloid leukemia
- bone marrow
- gene expression
- protein protein
- amino acid
- machine learning
- deep learning
- dna methylation
- genome wide analysis