Generally rare but occasionally severe weight gain after switching to an integrase inhibitor in virally suppressed AGEhIV cohort participants.

Sebastiaan O VerboeketAnders BoydFerdinand W WitEveline VerheijMaarten F Schim van der LoeffNeeltje KootstraMarc van der ValkPeter Reissnull null

Published in: PloS one (2021)

Switching to INSTI-containing ART in our cohort of predominantly white men on long-term ART was not associated with greater mean weight gain, but >5% weight gain was more common than in controls. These results suggest that not all, but only certain, PWH may be particularly prone to gain a clinically significant amount of weight as a result of switching to INSTI.

Keyphrases

weight gain
body mass index
birth weight
weight loss
hiv infected
antiretroviral therapy
early onset
middle aged
african american