Oxidative Free-Radical C(sp 2 )-H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α-Chlorinated Enaminones.

An oxidative free-radical C(sp 2 )-H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K 2 S 2 O 8 as an oxidant. This transformation provides a new and straightforward synthetic methodology to afford highly functionalized α-chlorinated enaminones with a Z -configuration in good to excellent yields.