Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis.

Olaf EickmeierDaniela FussbroichKlaus MuellerFriederike ServeChristina SmacznyStefan ZielenRalf Schubert

Published in: PloS one (2017)

SPMs, like RvD1, are well known to down-regulate inflammatory pathways. Our study shows that the bioactive lipid mediator RvD1, derived from DHA, was present in sputum and plasma of CF patients and may serve as a representative peripheral biomarker of the lung resolution program for CF patients.

Keyphrases

cystic fibrosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
mycobacterium tuberculosis
oxidative stress