Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study.

Ewelina KoziołKrystyna Skalicka WoźniakAgnieszka MichalakKatarzyna KaszubskaBarbara Budzyńska

Published in: Pharmacological reports : PR (2020)

The similar activity of the same substance in two different animal models indicates their compatibility and proves the potential of in vivo bioassays based on zebrafish models. Results of our study indicate that xanthotoxin may be considered as a potential lead compound in the discovery of antiparkinsonian drugs.

Keyphrases

small molecule
human health
high throughput
high fat diet induced
risk assessment
adipose tissue
metabolic syndrome
climate change
skeletal muscle
depressive symptoms
aedes aegypti
drug induced