Oxidative DNA damage promotes vascular aging associated with changes in extracellular matrix-regulating proteins.
Kirsty FooteMarieke RienksLukas SchmidtKonstantinos TheofilatosYasmin YasminMatiss OzolsAlexander EckersleyAarti ShahNichola FiggAlison FiniganKevin O'ShaughnessyIan B WilkinsonManuel MayrMartin R BennettPublished in: Cardiovascular research (2024)
Vascular aging is associated with oxidative DNA damage, downregulation of major BER proteins, and changes in multiple ECM structural and regulatory proteins. Ogg1 protects against vascular aging, associated with changes in ECM regulatory proteins including LOX and WISP2.