Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits ⍺-1,3-fucose epitope-specific inverse associations with asthma.
Gyaviira NkurunungiHarriet MpairweSerge A VersteegAngela van DiepenJacent NassuunaJoyce KabagenyiIrene NambuyaRichard E SanyaMargaret NampijjaSonia SernaNiels-Christian ReichardtCornelis H HokkeEmily L WebbRonald van ReeMaria YazdanbakhshAlison M ElliottPublished in: Allergy (2020)
CCD reactivity is not just an epiphenomenon of parasite exposure hampering specificity of allergy diagnostics; mechanistic studies should investigate whether specific CCD moieties identified here are implicated in the protective effect of certain environmental exposures against asthma.