The utility of human two plus one small pronucleated zygotes (2.1PN) based on clinical outcomes and the focused ploidy analysis.
Hiromitsu HattoriNoriyuki OkuyamaKyota AshikawaYoshiyuki SakurabaHideki IgarashiKoichi KyonoPublished in: Journal of assisted reproduction and genetics (2024)
It was suggested that 2.1PN embryos have lower embryonic developmental potential than 2PN embryos, but most of the 2.1PN were diploid, indicating that they are likely to be clinically usable. It is recommended to perform embryo transfer following a combination of PGT-A and ploidy analysis.