Inhaled nitric oxide in patients with acute respiratory distress syndrome caused by COVID-19: treatment modalities, clinical response, and outcomes.
Armand Mekontso DessapLaurent PapazianManuella SchallerSaad NseirBruno MegarbaneLuc HaudebourgJean-François TimsitJean-Louis TeboulKhaldoun KuteifanMarc GainnierMichel SlamaPatrick HouetoLaurent LecourtAlain MercatAntoine Vieillard-BaronPublished in: Annals of intensive care (2023)
Our study reports the benefits of iNO in improving arterial oxygenation in C-ARDS patients. This improvement seems more relevant in the most severe cases. In patients with ECMO criteria, an iNO-driven improvement in gas exchange was associated with better survival. These results must be confirmed in well-designed prospective studies.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- nitric oxide
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- coronavirus disease
- sars cov
- prognostic factors
- hydrogen peroxide
- patient reported outcomes
- type diabetes
- early onset
- replacement therapy
- free survival