The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus )proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist.

Ekaterina I Lesnova Olga V Masalova K Y Permyakova Natalya A Demidova Vladimir T Valuev-Elliston Alexander V Ivanov Vladimir T Valuev-Elliston

Published in: Voprosy virusologii (2023)

Different immunogenic properties and different functions of recombinant non-structural HCV proteins indicate the feasibility of their combined inclusion in subunit vaccines. It was established for the first time that immunization with HCV proteins with a complex adjuvant (polymuramyl + pyrogenalum) has a synergistic effect, significantly exceeding the effect of each of them separately.

Keyphrases

hepatitis c virus
human immunodeficiency virus
early stage
immune response
toll like receptor
inflammatory response
type diabetes
high fat diet induced
innate immune
adipose tissue
metabolic syndrome
hiv infected