Intratumoural haematopoietic stem and progenitor cell differentiation into M2 macrophages facilitates the regrowth of solid tumours after radiation therapy.
Tyler M ParsonsKatie L BuelowAlaa HannaMarisa A BrakeCrystal PomaSarah E HoschRandal J WestrickLuis G Villa-DiazGeorge D WilsonGerard J MadlambayanPublished in: British journal of cancer (2021)
Tumours coopt intratumoural HSPC fate determination via CSF-1 signaling to overcome the effects of RT. Thus, limiting intratumoural HSPC activity represents an attractive strategy for improving the clinical treatment of solid tumours.