Molybdenum disulfide-gold nanoparticle nanocomposite in field-effect transistor back-gate for enhanced C-reactive protein detection.
N R DalilaM K Md ArshadSubash C B GopinathM N M NuzaihanM F M FathilPublished in: Mikrochimica acta (2020)
Nanofabricated gold nanoparticles (Au-NPs) on MoS2 nanosheets (Au-NPs/MoS2) in back-gated field-effect transistor (BG-FET) are presented, which acts as an efficient semiconductor device for detecting a low concentration of C-reactive protein (C-RP). The decorated nanomaterials lead to an enhanced electron conduction layer on a 100-μm-sized transducing channel. The sensing surface was characterized by Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), atomic force microscopy (AFM), scanning electron microscopy (SEM), and high-power microscopy (HPM). The BG-FET device exhibits an excellent limit of detection of 8.38 fg/mL and a sensitivity of 176 nA/g·mL-1. The current study with Au-NPs/MoS2 BG-FET displays a new potential biosensing technology; especially for integration into complementary metal oxide (CMOS) technology for hand-held future device application.
Keyphrases
- reduced graphene oxide
- electron microscopy
- gold nanoparticles
- atomic force microscopy
- single molecule
- high speed
- label free
- raman spectroscopy
- high resolution
- quantum dots
- sensitive detection
- loop mediated isothermal amplification
- oxide nanoparticles
- visible light
- real time pcr
- room temperature
- current status
- risk assessment
- climate change
- solid state
- highly efficient