In-ICU-acquired infections in flare-up systemic rheumatic disease patients receiving immunosuppressant.
Florence AssanPierre BayAlexis MathianGuillaume HekimianNicolas BréchotPaul QuentricQuentin MoyonMatthieu SchmidtFleur Cohen-AubartJulien HarocheZahir AmouraCharles-Edouard LuytAlain CombesMarc Pineton de ChambrunPublished in: Clinical rheumatology (2022)
In-ICU-acquired infection in SRD flare-up is a frequent event associated with organ failures but not with in-ICU use of immunosuppressants. These data suggest that the fear of infection should not withhold a careful in-ICU use of immunosuppressive drugs. Key Points • In-ICU infections are frequent in flare-up systemic rheumatic disease patients. • Infections are associated with increased mortality. • Cyclophosphamide given in ICU was not independently associated with infection. • Severe neutropenia occurred in 27% of patients receiving cyclophosphamide in ICU.
Keyphrases
- intensive care unit
- mechanical ventilation
- low dose
- rheumatoid arthritis
- newly diagnosed
- end stage renal disease
- cardiovascular disease
- acute respiratory distress syndrome
- risk factors
- machine learning
- cardiovascular events
- deep learning
- electronic health record
- big data
- extracorporeal membrane oxygenation
- data analysis