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Single-cell analysis of localized prostate cancer patients links high Gleason score with an immunosuppressive profile.

Victor Adorno FeblesYuan HaoAarif AhsanJiansheng WuYingzhi QianHua ZhongStacy LoebDanil V MakarovHerbert LeporJames WysockSamir S TanejaWilliam C HuangDaniel J BeckerArjun V BalarJonathan MelamedFang-Ming DengQinghu RenDonald W KufeKwok-Kin WongDennis O AdeegbeJiehui DengDavid R Wise
Published in: The Prostate (2023)
T cell exhaustion in localized PCa, a finding enriched in HGPCa relative to LGPCa. These studies suggest a possible link between the clinical-pathologic risk of PCa and the associated TME. Our results have implications for our understanding of the immunologic mechanisms of PCa pathogenesis and the implementation of immunotherapy for localized PCa.
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