Baseline renal function and adverse outcomes in pregnancies complicated by pregestational diabetes.
Macie L ChampionRobin SteeleRachel SinkeyAlan T TitaLorie M HarperPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)
Creatinine was not associated with adverse pregnancy outcomes at thresholds <1.2 mg/dL in women with pregestational diabetes. Those with a baseline UPC ≥ 0.21 have an increased risk of preeclampsia and preterm delivery. Baseline 24 hr urine protein should be obtained in these patients to aid in counseling and future diagnosis of preeclampsia.Key PointsBaseline renal function tests are recommended in patients with pregestational diabetes, but values associated with pregnancy risk are poorly defined.This study evaluated the relationship between baseline renal function tests in patients with pregestational diabetes and adverse pregnancy outcomes.We found urine protein to creatinine ratio ≥0.21 to be associated with the development of severe preeclampsia <34 weeks gestational age as well as preeclampsia at any gestational age.
Keyphrases
- pregnancy outcomes
- gestational age
- preterm birth
- birth weight
- pregnant women
- type diabetes
- cardiovascular disease
- glycemic control
- early onset
- end stage renal disease
- ejection fraction
- low birth weight
- newly diagnosed
- chronic kidney disease
- adipose tissue
- insulin resistance
- preterm infants
- prognostic factors
- small molecule
- hiv infected
- weight gain