Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review.
Biswajita PradhanRabindra NayakSrimanta PatraBimal Prasad JitAndrea RagusaMrutyunjay JenaPublished in: Molecules (Basel, Switzerland) (2020)
In addition to cancer and diabetes, inflammatory and ROS-related diseases represent one of the major health problems worldwide. Currently, several synthetic drugs are used to reduce oxidative stress; nevertheless, these approaches often have side effects. Therefore, to overcome these issues, the search for alternative therapies has gained importance in recent times. Natural bioactive compounds have represented, and they still do, an important source of drugs with high therapeutic efficacy. In the ''synthetic'' era, terrestrial and aquatic photosynthetic organisms have been shown to be an essential source of natural compounds, some of which might play a leading role in pharmaceutical drug development. Marine organisms constitute nearly half of the worldwide biodiversity. In the marine environment, algae, seaweeds, and seagrasses are the first reported sources of marine natural products for discovering novel pharmacophores. The algal bioactive compounds are a potential source of novel antioxidant and anticancer (through modulation of the cell cycle, metastasis, and apoptosis) compounds. Secondary metabolites in marine Algae, such as phenolic acids, flavonoids, and tannins, could have great therapeutic implications against several diseases. In this context, this review focuses on the diversity of functional compounds extracted from algae and their potential beneficial effects in fighting cancer, diabetes, and inflammatory diseases.
Keyphrases
- oxidative stress
- cell cycle
- dna damage
- type diabetes
- papillary thyroid
- cardiovascular disease
- ischemia reperfusion injury
- mental health
- ms ms
- diabetic rats
- induced apoptosis
- squamous cell
- cell death
- risk assessment
- public health
- endothelial cells
- cell proliferation
- gram negative
- endoplasmic reticulum stress
- squamous cell carcinoma
- glycemic control
- adipose tissue
- reactive oxygen species
- metabolic syndrome
- social media
- climate change
- health information
- cell cycle arrest
- induced pluripotent stem cells
- multidrug resistant
- drug induced