Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging.
Yasuhisa TamuraKayo TakahashiKumi TakataAsami EguchiMasanori YamatoSatoshi KumeMasayuki NakanoYasuyoshi WatanabeYosky KataokaPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Adult hippocampal neurogenesis may play a role in major depression and antidepressant therapy. Establishment of in vivo imaging for hippocampal neurogenic activity may be useful to diagnose depression and monitor the therapeutic efficacy of antidepressants. Positron emission tomography (PET) imaging has been studied to allow visualization of neurogenic activity; however, PET imaging has not been widely used due to the lower accumulation of the PET tracer in the neurogenic regions. Here, we succeeded in establishing highly quantitative PET imaging for neurogenic activity in adult brain with an inhibitor for drug transporter. This enhanced PET imaging allowed evaluation of the decline of neurogenic activity in the hippocampus of rats with depression and the recovery of neurogenic activity by antidepressant treatment.
Keyphrases
- pet imaging
- positron emission tomography
- spinal cord injury
- computed tomography
- cerebral ischemia
- depressive symptoms
- major depressive disorder
- high resolution
- pet ct
- emergency department
- acute myeloid leukemia
- multiple sclerosis
- mass spectrometry
- mesenchymal stem cells
- subarachnoid hemorrhage
- tyrosine kinase
- blood brain barrier