FXR agonists INT-787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet-induced ob/ob mouse model of NASH.

Laura G Di PasquaMarta CagnaGiuseppina PalladiniAnna C CroceMassimiliano CadamuroLuca FabrisStefano PerliniLuciano AdoriniAndrea Ferrigno Giuseppina Palladini

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

INT-787 is superior to OCA in controlling specific cell types and clinically relevant anti-inflammatory and antifibrotic molecular mechanisms in NASH.

Keyphrases

mouse model
anti inflammatory
oxidative stress
single cell
insulin resistance
cell therapy
high fat diet
stem cells
metabolic syndrome
type diabetes
pulmonary fibrosis
high fat diet induced
mesenchymal stem cells
skeletal muscle