CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.
Matthew L KleinjanDe Yu MaoL A NaicheJagdish Chandra JoshiAhana GuptaJordan J JesseDaniel D ShayeDolly MehtaJan K KitajewskiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
CLIC4 is a critical effector of endothelial PAR1 signaling and is required to regulate RhoA-mediated endothelial barrier disruption in cultured endothelial cells and murine lung endothelium. CLIC1 was not critical for thrombin-mediated barrier disruption but contributed to the barrier recovery phase after thrombin treatment.