Colistin-resistance genes in Escherichia coli isolated from patients with urinary tract infections.
Waleed M Al MomaniNour AtaAhmed O MaslatPublished in: PloS one (2024)
To our knowledge, this is the first report on the presence of plasmid-coded MCR-1 in E. coli from a patient with UTIs in Jordan. This is a problematic finding because colistin is the last-line drug for the treatment of infections caused by MDR gram-negative bacteria. There is a crucial need to robustly utilize antibiotics to control and prevent the emergence and prevalence of colistin-resistance genes.
Keyphrases
- escherichia coli
- urinary tract infection
- klebsiella pneumoniae
- genome wide
- multidrug resistant
- biofilm formation
- bioinformatics analysis
- genome wide identification
- healthcare
- risk factors
- case report
- acinetobacter baumannii
- genome wide analysis
- drug resistant
- pseudomonas aeruginosa
- emergency department
- gram negative
- gene expression
- crispr cas
- combination therapy