Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging.

Whitney M Freeze D N Ter Weele W M Palm Roy W E van Hooren Erik Hoff Jacobus F A Jansen Heidi I L Jacobs Frans Rochus Josef Verhey Walter H Backes

Published in: AJNR. American journal of neuroradiology (2019)

Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.

Keyphrases

blood brain barrier
cerebral ischemia
loop mediated isothermal amplification
contrast enhanced
real time pcr

label free
endothelial cells
magnetic resonance
high resolution

magnetic resonance imaging
small cell lung cancer
convolutional neural network
machine learning

mass spectrometry
image quality
fluorescence imaging
case control