Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology.
Anna Karin HedströmNicole BrennerJulia ButtJan HillertTim WaterboerTomas OlssonLars AlfredssonPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
With regard to MS risk, overweight/obesity in young adulthood acts synergistically with both aspects of EBV infection, predominantly among those with a genetic susceptibility to the disease. The obese state both induces a chronic immune-mediated inflammation and affects the cellular immune response to infections, which may contribute to explain our findings.
Keyphrases
- weight loss
- weight gain
- bariatric surgery
- epstein barr virus
- metabolic syndrome
- mass spectrometry
- insulin resistance
- multiple sclerosis
- type diabetes
- ms ms
- diffuse large b cell lymphoma
- depressive symptoms
- middle aged
- oxidative stress
- high fat diet induced
- adipose tissue
- body mass index
- early life
- physical activity
- obese patients
- genome wide
- gene expression
- copy number