Phentolamine Significantly Enhances Macrolide Antibiotic Antibacterial Activity against MDR Gram-Negative Bacteria.
Ze-Hua CuiHui-Ling HeZi-Jian ZhengZhao-Qi YuanYing ChenXin-Yi HuangHao RenYu-Feng ZhouDong-Hao ZhaoLiang-Xing FangYang YuYa-Hong LiuXiao-Ping LiaoJian SunPublished in: Antibiotics (Basel, Switzerland) (2023)
Phentolamine potentiates macrolide antibiotic activity via reducing efflux pump activity and direct damage to the outer membrane leaflet of Gram-negative bacteria both in vitro and in vivo.
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