Local CpG density affects the trajectory and variance of age-associated DNA methylation changes.

Jonathan HighamLyndsay KerrQian ZhangRosie M WalkerSarah E HarrisDavid M HowardEmma L HawkinsAnca-Larisa SanduJ Douglas SteeleGordon D WaiterAlison D MurrayKathryn L EvansAndrew M McIntoshPeter M VisscherIan J DearySimon R CoxDuncan Sproul

Published in: Genome biology (2022)

Our results, which we reproduce in two independent groups of individuals, demonstrate that local DNA sequence influences age-associated DNA methylation changes in humans in vivo. We suggest that this occurs because interactions between CpGs reinforce maintenance of methylation patterns in CpG dense regions.

Keyphrases

dna methylation
genome wide
gene expression
circulating tumor
copy number
single molecule
nucleic acid