Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
Ching-Ti LiuDavid KarasikHanfei XuYanhua ZhouKerry BroeL Adrienne CupplesLisette Cpgm de GrootAnnelies HamMarian T HannanYi-Hsiang HsuPaul JacquesRobert R McLeanLigi PaulJacob SelhubKaterina TrajanoskaNathalie van der VeldeNatasja van SchoorDouglas P KielPublished in: The American journal of clinical nutrition (2021)
Some genetic variants in the 1-carbon methylation pathway modify the association of B vitamin and biomarker concentrations with bone density and strength. These interactions require further replication and functional validation for a mechanistic understanding of the role of the 1-carbon metabolism pathway on BMD and risks of fracture.